Settleman, Jeff: search on Z-Library

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1

TORquing metabolic reprogramming in cancer cells

Pusapati, Raju, Settleman, Jeff

Journal:

Year:

2016

Language:

english

File:

PDF, 926 KB

english, 2016

2

From Cancer Genomics to Precision Oncology—Tissue’s Still an Issue

Cohen, Robert L., Settleman, Jeff

Journal:

Year:

2014

Language:

english

File:

PDF, 415 KB

english, 2014

3

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

Jänne, Pasi A., Gray, Nathanael, Settleman, Jeff

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 755 KB

english, 2009

4

Communication in Drug Development: “Translating” Scientific Discovery

Settleman, Jeff, Cohen, Robert L.

Journal:

Year:

2016

Language:

english

File:

PDF, 375 KB

english, 2016

5

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers

Timothy R. Wilson, Diana Y. Lee, Leanne Berry, David S. Shames, Jeff Settleman

Journal:

Year:

2011

Language:

english

File:

PDF, 1.60 MB

english, 2011

6

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

Sahu, Nisebita, Stephan, Jean-Philippe, Cruz, Darlene Dela, Merchant, Mark, Haley, Benjamin, Bourgon, Richard, Classon, Marie, Settleman, Jeff

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

7

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers

Anurag Singh, Michael F. Sweeney, Min Yu, Alexa Burger, Patricia Greninger, Cyril Benes, Daniel A. Haber, Jeff Settleman

Journal:

Year:

2012

Language:

english

File:

PDF, 2.08 MB

english, 2012

8

Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreaticductal adenocarcinoma

Sahu, Nisebita, Chan, Emily, Chu, Felix, Pham, Thinh, Koeppen, Hartmut, Forrest, William, Merchant, Mark, Settleman, Jeff

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 4.16 MB

english, 2017

9

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

Anurag Singh, Patricia Greninger, Daniel Rhodes, Louise Koopman, Sheila Violette, Nabeel Bardeesy, Jeff Settleman

Journal:

Year:

2009

Language:

english

File:

PDF, 2.00 MB

english, 2009

10

Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?

Cyril Benes, Jeff Settleman

Journal:

Year:

2009

Language:

english

File:

PDF, 175 KB

english, 2009

11

Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis

Robert L Yauch, Jeff Settleman

Journal:

Current Opinion in Genetics & Development

Year:

2012

Language:

english

File:

PDF, 221 KB

english, 2012

12

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

Sahu, Nisebita, Dela Cruz, Darlene, Gao, Min, Sandoval, Wendy, Haverty, Peter M., Liu, Jinfeng, Stephan, Jean-Philippe, Haley, Benjamin, Classon, Marie, Hatzivassiliou, Georgia, Settleman, Jeff

Journal:

Cell Metabolism

Year:

2016

Language:

english

File:

PDF, 3.71 MB

english, 2016

13

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Wilson, Catherine, Nicholes, Katrina, Bustos, Daisy, Lin, Eva, Song, Qinghua, Stephan, Jean-Philippe, Kirkpatrick, Donald S., Settleman, Jeff

Journal:

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

14

Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation

Wang, Victoria E., Xue, Jenny Y., Frederick, Dennie T., Cao, Yi, Lin, Eva, Wilson, Catherine, Urisman, Anatoly, Carbone, David P., Flaherty, Keith T., Bernards, Rene, Lito, Piro, Settleman, Jeff, McCo

Journal:

Clinical Cancer Research

Year:

2019

File:

PDF, 2.47 MB

2019

15

Cancer: miRNA Addiction — Depending On Life's Little Things

David Dornan, Jeff Settleman

Journal:

Current Biology

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

16

DOCK4, a GTPase Activator, Is Disrupted during Tumorigenesis

Vijay Yajnik, Charles Paulding, Raffaella Sordella, Andrea I. McClatchey, Mako Saito, Doke C.R. Wahrer, Paul Reynolds, Daphne W. Bell, Robert Lake, Sander van den Heuvel, Jeff Settleman, Daniel A. Hab

Journal:

Year:

2003

Language:

english

File:

PDF, 486 KB

english, 2003

17

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells

Sun, Yuting, Daemen, Anneleen, Hatzivassiliou, Georgia, Arnott, David, Wilson, Catherine, Zhuang, Guanglei, Gao, Min, Liu, Peter, Boudreau, Aaron, Johnson, Leisa, Settleman, Jeff

Journal:

Cancer & Metabolism

Year:

2014

Language:

english

File:

PDF, 3.00 MB

english, 2014

18

Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

Lee, Ho-June, Cao, Yi, Pham, Victoria, Blackwood, Elizabeth, Wilson, Catherine, Evangelista, Marie, Klijn, Christiaan, Stokoe, David, Settleman, Jeff

Journal:

Molecular Cancer Therapeutics

Year:

2017

File:

PDF, 762 KB

2017

19

A three-drug combination to treat BRAF-mutant cancers

Firestone, Ari J, Settleman, Jeff

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 1.03 MB

english, 2017

20

Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein

Deuker, Marian M., Lewis, Kaitlyn N., Ingaramo, Maria, Kimmel, Jacob, Buffenstein, Rochelle, Settleman, Jeff

Journal:

Scientific Reports

Year:

2020

File:

PDF, 7.52 MB

2020

21

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

Sharma, Sreenath V., Haber, Daniel A., Settleman, Jeff

Journal:

Nature Reviews Cancer

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

22

Rho family GTPases: more than simple switches

Marc Symons, Jeff Settleman

Journal:

Trends in Cell Biology

Year:

2000

Language:

english

File:

PDF, 102 KB

english, 2000

23

A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on Skin

Journal:

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

24

Cancer: Drivers and passengers

Haber, Daniel A., Settleman, Jeff

Journal:

Year:

2007

Language:

english

File:

PDF, 357 KB

english, 2007

25

Cancer: Bet on drug resistance

Settleman, Jeff

Journal:

Year:

2016

Language:

english

File:

PDF, 183 KB

english, 2016

26

Targeting the RAF–MEK–ERK pathway in cancer therapy

Clara Montagut, Jeff Settleman

Journal:

Year:

2009

Language:

english

File:

PDF, 363 KB

english, 2009

27

Exploiting the balance between life and death: Targeted cancer therapy and “oncogenic shock”

Sreenath V. Sharma, Jeff Settleman

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 322 KB

english, 2010

28

Dissecting cancer heterogeneity

Dornan, David, Settleman, Jeff

Journal:

Nature Biotechnology

Year:

2011

Language:

english

File:

PDF, 1011 KB

english, 2011

29

Mechanisms of acquired resistance to targeted cancer therapies

Lackner, Mark R, Wilson, Timothy R, Settleman, Jeff

Journal:

Future Oncology

Year:

2012

Language:

english

File:

PDF, 1009 KB

english, 2012

30

Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells

Mehta, Anita K., Hua, Kevin, Whipple, William, Nguyen, Minh-Thuy, Liu, Ching-Ti, Haybaeck, Johannes, Weidhaas, Joanne, Settleman, Jeff, Singh, Anurag

Journal:

Science Signaling

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

31

Optimizing the treatment of BRAF mutant melanoma

Journal:

Genome Medicine

Year:

2014

Language:

english

File:

PDF, 126 KB

english, 2014

32

A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells

Finn, Kenneth J, Martin, Scott E, Settleman, Jeff

Journal:

Cancer Research

Year:

2019

Language:

english

File:

PDF, 9.20 MB

english, 2019

33

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

Lee, Ho-June, Zhuang, Guanglei, Cao, Yi, Du, Pan, Kim, Hyo-Jin, Settleman, Jeff

Journal:

Year:

2014

Language:

english

File:

PDF, 3.69 MB

english, 2014

34

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

Pusapati, Raju V., Daemen, Anneleen, Wilson, Catherine, Sandoval, Wendy, Gao, Min, Haley, Benjamin, Baudy, Andreas R., Hatzivassiliou, Georgia, Evangelista, Marie, Settleman, Jeff

Journal:

Year:

2016

Language:

english

File:

PDF, 6.36 MB

english, 2016

35

Discovering Tumor Suppressor Genes Through Genome-Wide Copy Number Analysis

Michael Rothenberg, S., Settleman, Jeff

Journal:

Current Genomics

Year:

2010

Language:

english

File:

PDF, 383 KB

english, 2010

36

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

Bell, Daphne W, Gore, Ira, Okimoto, Ross A, Godin-Heymann, Nadia, Sordella, Raffaella, Mulloy, Roseann, Sharma, Sreenath V, Brannigan, Brian W, Mohapatra, Gayatry, Settleman, Jeff

Journal:

Nature Genetics

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

37

Cell Culture Modeling of Genotype-Directed Sensitivity to Selective Kinase Inhibitors: Targeting the Anaplastic Lymphoma Kinase (ALK)

Journal:

Seminars in Oncology

Year:

2009

Language:

english

File:

PDF, 162 KB

english, 2009

38

Reproducible pharmacogenomic profiling of cancer cell line panels

Haverty, Peter M., Lin, Eva, Tan, Jenille, Yu, Yihong, Lam, Billy, Lianoglou, Steve, Neve, Richard M., Martin, Scott, Settleman, Jeff, Yauch, Robert L., Bourgon, Richard

Journal:

Year:

2016

Language:

english

File:

PDF, 4.37 MB

english, 2016

39

Emerging concepts in tumor progression and therapy

Marie Classon, Jeff Settleman

Journal:

Seminars in Cancer Biology

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

40

Oncogenic K-ras “addiction” and synthetic lethality

Singh, Anurag, Settleman, Jeff

Journal:

Year:

2009

Language:

english

File:

PDF, 611 KB

english, 2009

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